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KMID : 0378019710140060083
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New Medical Journal
1971 Volume.14 No. 6 p.83 ~ p.88
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Inflammatory Reaction of Skin to Mixture of Inflammatory Exudate and Egg Albumin
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Abstract
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The experiment was carried out to ascertain whether there exists certain chemical mediator in inflamm￢atory exudate and serous fluid, and, if any, to compare injurious activity of the exudate or serous fluid and that of mixtures of the exudate or serous fluid and egg albumin. The exudate was prepared from the abdominal cavity of rabbits injected intraperitoneally with 0.2m1 of crotone oil. The serous fluid was obtained from the abdominal cavity of normal rabbits.
Each mixture was injected interadermally into the abdominal skin of normal rabbits and the local reaction was observed grossly at time intervals for 48 hours.
The results of this study are summarized as follow:
1. The inflammatory exudate and the mixture of inflammatory exudate and egg albumin all evoked inflammatory reaction. However, inflammatory reaction to the mixture was more marked than that to inflammatory exudate alone.
2. The mixture of serous fluid and egg albumin or serous fluid alone did not produced any significant injoury.
It is suggested that in inflammatory exudate, there exists not only active inflammation-inducing factor, but certain chemical mediator.
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